Preparation and Evaluation of Viloxazine Hydrochloride Bilayer Matrix Tablets
| Autor: | K. Nagasree, Uppalanchi Prashanthi, Ramya Sri S |
|---|---|
| Rok vydání: | 2023 |
| Zdroj: | Asian Journal of Research in Chemistry. :91-96 |
| ISSN: | 0974-4150 0974-4169 |
| DOI: | 10.52711/0974-4150.2023.00015 |
| Popis: | Aim of study was to develop bilayer drug delivery for treatment of attention deficit hyperactivity disorder (ADHD) by delivering loading and maintenance dose for fast achievement of peak plasma concentration and maintaining the same respectively. The prepared drug loaded bilayer tablets were evaluated for pre and post compression parameters. The tablets were prepared by direct compression and wet granulation method. The loading dose was delivered in the form of immediate release layer prepared by different super-disintegrations and maintenance dose was delivered through sustained release layer prepared by using polymers like Ethyl cellulose and Carbopol. Both the immediate release layer and sustained release layers were separately optimized and then combined to optimize the bilayer tablets. No interactions were found between drug and excipients. Formulation containing Cross Carmellose shows immediate drug release. Formulation Containing Carbopol shows sustained release action and bilayer formulations F5 shows releases up to 12 hours. Bilayer tablets with release characteristics offer critical advantages such as, site specificity with improved absorption and efficacy. |
| Databáze: | OpenAIRE |
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