Patch/plaque mycosis‐fungoides‐like presentations of DUSP22 ‐ translocated T‐cell lymphomas

Autor:	Naomi F. Briones, Trilokraj Tejasvi, Lori Lowe, Alexandra C. Hristov, John S. Runge, Ryan A. Wilcox, Daniel F. Boyer, Madison L. Novice, Kiyanna Williams
Rok vydání:	2021
Předmět:	Pathology medicine.medical_specialty Mycosis fungoides Histology CD30 business.industry Dermatology Gene rearrangement medicine.disease Pathology and Forensic Medicine Lymphoma Immunophenotyping Medicine T-cell lymphoma Lymphomatoid papulosis business Anaplastic large-cell lymphoma
Zdroj:	Journal of Cutaneous Pathology. 49:299-305
ISSN:	1600-0560 0303-6987
Popis:	The DUSP22-IRF4 gene rearrangement results in downregulation of DUSP22, a presumed tumor suppressor in T-cell lymphomagenesis. It has been described in some cases of primary cutaneous and systemic anaplastic large-cell lymphoma, lymphomatoid papulosis, and transformed mycosis fungoides. Here we describe two patients with clinical lesions resembling patch/plaque mycosis fungoides that did not meet WHO criteria for large-cell transformation on histopathology yet showed a DUSP22 translocation. One patient who had a history of systemic anaplastic large-cell lymphoma with DUSP22 translocation presented with cutaneous involvement by his systemic lymphoma along with lymphomatoid papulosis and mycosis-fungoides-like lesions, all showing an identical immunophenotype and T-cell clone. These cases expand the spectrum of DUSP22-rearranged lymphomas to include mycosis-fungoides-like presentations without large-cell transformation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f83c80e9d96c4f9577de3457b6453094 https://doi.org/10.1111/cup.14156 Zobrazit plný text záznamu Plný text