Natural Product Synthesis with Unnatural Results: Characterization of a Novel Fused Imidazolidinone Tetrahydropyrroloindole Ring System by Long-Range1H-15N 2D-NMR

Autor:	David J. Richard, Gary E. Martin, Madeleine M. Joullie, Chad E. Hadden
Rok vydání:	2003
Předmět:	chemistry.chemical_compound Natural product Indole alkaloid chemistry Imidazolidinone Stereochemistry Molecule General Medicine Ring (chemistry) Combinatorial chemistry Two-dimensional nuclear magnetic resonance spectroscopy Derivative (chemistry) Characterization (materials science)
Zdroj:	ChemInform. 34
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200333205
Popis:	Synthetic efforts towards the indole alkaloid natural product roquefortine C resulted in the formation of an unknown intermediate. Elucidation of the structure of this molecule relied on the use of long-range 1H-15N 2D-NMR. Computational predictions were used to facilitate the location of weak responses in long-range 1H-13C HMBC spectra. These methods provided conclusive evidence that this compound possessed a novel tetracycle. The complete 12H, 13C, and 15N chemical shift assignments of this unique fused imidazolidinone tetrahydropyrroloindole derivative are reported.
Databáze:	OpenAIRE
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