A metabolically healthy obese phenotype in hispanic participants in the IRAS family study
| Autor: | Jill M. Norris, Yii-Der Ida Chen, Kristen G. Hairston, Andrea Anderson, Xanthia F. Samaropoulos, Ann Scherzinger, Carlos Lorenzo, Lynne E. Wagenknecht, Maria G. Montez, Steven M. Haffner |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Population Medicine (miscellaneous) Adipose tissue 030209 endocrinology & metabolism Overweight Gastroenterology 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Nonalcoholic fatty liver disease medicine Glucose homeostasis 030212 general & internal medicine education education.field_of_study Nutrition and Dietetics business.industry medicine.disease Obesity 3. Good health Cohort medicine.symptom business Cohort study |
| Zdroj: | Obesity. 21:2303-2309 |
| ISSN: | 1930-7381 |
| Popis: | Objective: Some obese individuals appear to be protected from developing type 2 diabetes mellitus and cardiovascular disease (CVD). This has led to characterizing body size phenotypes based on cardiometabolic risk factors specifically as obese or overweight, and as metabolically healthy (MH) or metabolically abnormal (MA) based upon blood pressure, lipids, glucose homeostasis, and inflammatory parameters. The aim of this study was to measure the prevalence of and describe fat distribution across these phenotypes in a minority population. Design and Methods: Hispanic participants (N = 1054) in the IRAS Family Study were categorized into different body size phenotypes. Computed tomography (CT) abdominal scans were evaluated for measures of nonalcoholic fatty liver disease (NAFLD) and abdominal fat distribution. Statistical models adjusting for familial relationships were estimated. Results: Seventy percent (70%) of the Hispanic cohort was overweight (32%) or obese (38%). Forty-one percent (n = 138) of overweight participants and 19% (n = 74) of obese participants met criteria for MH. Adjusted analyses showed the MH phenotype was associated with lower visceral adipose tissue (VAT) and higher liver density (indicating lower fat content) in obese participants (p = 0.0005 and p = 0.0002, respectively), and lower VAT but not liver density in overweight participants (p = 0.008 and p = 0.162, respectively) compared to their MA counterparts. Odds of NAFLD were reduced in MH obese (OR = 0.34, p = 0.0007) compared to MA obese. VAT did not differ between MH obese or overweight and normal weight groups. Conclusions: These findings suggest that lower levels of visceral and liver fat, despite overall increased total body fat, may be a defining feature of MH obesity in Hispanic Americans. |
| Databáze: | OpenAIRE |
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