Endotyping Chronic Rhinosinusitis with Nasal Polyps: Understanding Inflammation Beyond Phenotypes

Autor:	Chongjia C. Chen, Kathleen M. Buchheit
Rok vydání:	2023
Předmět:	Otorhinolaryngology Immunology and Allergy General Medicine
Zdroj:	American Journal of Rhinology & Allergy. 37:132-139
ISSN:	1945-8932 1945-8924
DOI:	10.1177/19458924221149003
Popis:	Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogenous group of inflammatory conditions impacting the nose and paranasal sinuses. Our understanding of the underlying pathobiology of CRSwNP has substantially improved due to ongoing translational research efforts. Advances in treatment options, including targeted respiratory biologic therapy for CRSwNP, allow for more personalized approaches for CRSwNP patient care. Patients with CRSwNP are typically classified to one or more endotype based on the presence of type 1, type 2, and type 3 inflammation. This review will discuss recent advances in our understanding of CRSwNP and how this may impact current and future treatment approaches for patients with CRSwNP.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f82ce57be9c96ee8ea267b13c348aaa3 https://doi.org/10.1177/19458924221149003 Zobrazit plný text záznamu