Abstract 9: Oxidative stress and antioxidant status in high-risk prostate cancer subjects
| Autor: | Akbar Nawab, Claudia Lillibridge, Sanjay Gupta, Lee Ponsky, Gregory T. MacLennan, Haripaul Sharma, Janmejai K. Srivastava, Sanjeev Shukla, Pingfu Fu, Rajnee Kanwal, Natarajan Bhaskaran |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
chemistry.chemical_classification
Cancer Research medicine.medical_specialty Lipid peroxide business.industry Glutathione peroxidase Glutathione reductase Cancer Glutathione medicine.disease_cause medicine.disease chemistry.chemical_compound Prostate cancer Endocrinology medicine.anatomical_structure Oncology chemistry Prostate Internal medicine medicine business Oxidative stress |
| Zdroj: | Cancer Research. 73:9-9 |
| ISSN: | 1538-7445 0008-5472 |
| Popis: | Prostate cancer is the most commonly diagnosed cancer among men in the United States. Epidemiological, experimental and clinical studies have implicated chronic inflammation and oxidative stress in the development and progression of prostate cancer. Diet, environmental carcinogens, aging, and other inflammatory diseases cause aberration in reactive oxygen species (ROS) which may play critical roles in the development and progression of prostate cancer. Chronic inflammation results in lipid peroxidation and generation of highly reactive products with the potential to damage DNA. The extent of ROS-induced oxidative damage can be determined by measuring reductions in levels of endogenous antioxidant defense enzymes such as glutathione-s-transferase (GST), glutathione peroxidase (GSH-Px), glutathione reductase (GSH-R), catalase (CAT), superoxide dismutase (SOD) and non-protein thiols, which participate in detoxification processes. The aim of this study was to assess the oxidative status and antioxidant defense mechanisms in 20 men, 54-84 years of age, with increased risk of developing prostate cancer because of the presence of high-grade prostatic intraepithelial neoplasia (HGPIN) in their prostate biopsies, as compared to 20 healthy men in the same age range whose prostate biopsies showed no evidence of HGPIN. Total glutathione levels were measured in red blood cells, and plasma levels of GSH-Px, GSH-R, CAT, SOD, and PSA were analyzed. Data obtained after analysis was represented as mean, standard error and box plot. Serum PSA levels were significantly (p Citation Format: Sanjeev Shukla, Janmejai K. Srivastava, Rajnee Kanwal, Akbar Nawab, Haripaul Sharma, Natarajan Bhaskaran, Claudia Lillibridge, Lee E. Ponsky, Pingfu Fu, Gregory T. MacLennan, Sanjay Gupta. Oxidative stress and antioxidant status in high-risk prostate cancer subjects. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 9. doi:10.1158/1538-7445.AM2013-9 |
| Databáze: | OpenAIRE |
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