| Popis: |
Small molecular weight peptides related to the well-known chemotactic peptide N -α-formyl-methionyl-leucyl-phenylalanine have been prepared. These compounds were designed to evaluate the requirements in position 3 (phenylalanine). Each analogue containing an α-substituted glycine in position 3 was tested for its ability to induce lysosomal enzyme release from cytochalasin B treated human neutrophils. In addition, each analogue was also tested for its ability to antagonize superoxide generation. The results indicate that the analogue N -formyl-methionyl-leucyl-(α-anilino)glycine allyl ester is a potent antagonist of superoxide generation. Its ID 50 's suggest that this compound could be very promising in the field of anti-inflammatory drugs. A hypothetical inhibition mechanism is discussed. |
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