ChemInform Abstract: Synthesis and Biological Activity of a Novel Class of Cephalosporins with a Oxadiazolyl Hydroxypyridone Moiety at C-7

Autor:	H. Fukuda, K. Hirai, Kikoh Obi, Akihiko Kojima
Rok vydání:	2010
Předmět:	Stereochemistry medicine.drug_class In vivo Chemistry Biological property Antibiotics Cephalosporin medicine Potency Moiety Biological activity General Medicine In vitro
Zdroj:	ChemInform. 27
ISSN:	0931-7597
DOI:	10.1002/chin.199614287
Popis:	Synthesis and biological properties of a novel class of cephalosporins with a 2-[5-(3-hydroxy-4-pyridon-6-yl)1,3,4-oxadiazol-2-yl]thioethyl group at C-7 position are described. Among them, the compounds having a pyridiniumthiomethyl group at C-3 position were found to possess high in vitro potency and showed excellent in vivo efficacy against both S. aureus and P. aeruginosa .
Databáze:	OpenAIRE
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