Synthesis and bio-evaluation of phenothiazine derivatives as new anti-tuberculosis agents

Autor:	Huaqing Cui, Xiang Zhang, Chun-Xian He, Dali Yin, Hui Meng
Rok vydání:	2015
Předmět:	biology General Chemistry Pharmacology biology.organism_classification Mycobacterium tuberculosis chemistry.chemical_compound Anti tuberculosis chemistry Phenothiazine Mammalian cell medicine Cytotoxicity Chlorpromazine medicine.drug
Zdroj:	Chinese Chemical Letters. 26:951-954
ISSN:	1001-8417
DOI:	10.1016/j.cclet.2015.03.027
Popis:	Two series of phenothiazine derivatives were designed and synthesized. All compounds were tested for anti-tuberculosis activities against Mycobacterium tuberculosis H37RV. In comparison with mother compound of chlorpromazine, compound 6e shows promising anti-tuberculosis activity and much less mammalian cell cytotoxicity, compound 6e merits to be further explored as new anti-tuberculosis agents.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f81e655f970b2fe35a0a98093fc58004 https://doi.org/10.1016/j.cclet.2015.03.027 Zobrazit plný text záznamu Full Text from ScienceDirect