Study of serotonin effects on histogenesis of embryonic rat neocortex on a model of ectopic neurotransplantation
| Autor: | Otellin Va, E. S. Petrova |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Neocortex biology Physiology Histogenesis Biochemistry Embryonic stem cell Cell biology Neuroepithelial cell Endocrinology medicine.anatomical_structure Serotonin inhibitor Internal medicine biology.protein medicine Serotonin NeuN Mitosis Ecology Evolution Behavior and Systematics |
| Zdroj: | Journal of Evolutionary Biochemistry and Physiology. 43:587-592 |
| ISSN: | 1608-3202 0022-0930 |
| Popis: | A comparative study of dynamics of development of ectopic grafts of the embryonic (E14) neocortical anlagen obtained from intact rats, rats injected with serotonin inhibitor para-chlorophe-nylalanine (PCPA) on the 11th day of pregnancy as well as the same anlagen incubated before grafting in the serotonin-containing medium. The aim of the study was to reveal influence of serotonin on division and differentiation of the embryonic neocortical cells. Investigation of degeneration, mitotic activity and differentiation (using immunohistochemical revealing of the nuclear protein of nervous cells (NeuN)) of the grafted cells demonstrated contribution of serotonin to survival and differentiation of neuroepithelial cells of the grafts and also to regulation of their proliferation. Serotonin is supposed to have a stimulatory effect on the rate of cellular cycle of the grafted cells, thereby accelerating differentiation of neurons. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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