Enantioselective synthesis of chiral 5-carbamoyl-3-pyridyl alcohols by asymmetric autocatalytic reaction

Autor:	Tadakatsu Hayase, Shigehisa Tanji, Kenso Soai, Takanori Shibata, Hiroshi Morioka, Yasutaka Kodaka
Rok vydání:	1996
Předmět:	Diisopropylzinc chemistry.chemical_classification Organic Chemistry Enantioselective synthesis Soai reaction Alkylation Biochemistry Medicinal chemistry Catalysis chemistry.chemical_compound chemistry Amide Drug Discovery Alkoxide Organic chemistry Alkyl
Zdroj:	Tetrahedron Letters. 37:8783-8786
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(96)02031-x
Popis:	A catalytic amount of a chiral zinc alkoxide of 5-carbamoyl-3-pyridyl alkyl alcohol catalyzes an enantioselective alkylation of 5-carbamoylpyridine-3-carbaldehyde by diisopropylzinc to afford itself in up to 86% e.e. with the same configuration as the catalyst. Enantioselectivity is dependent on the structure of substituents on the nitrogen atom of the amide.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f8159f9d29f2dc81c51c911f162d96a1 https://doi.org/10.1016/s0040-4039(96)02031-x Zobrazit plný text záznamu Full Text from ScienceDirect