Methylation of Quercetin by Diazomethane and Hypoglycemic Activity of its Tetra-O-Methyl Ether

Autor:	E. R. Karimova, T. A. Sapozhnikova, S. F. Gabdrakhmanova, N. S. Makara, Leonid V. Spirikhin, Baltina Lidiya A
Rok vydání:	2020
Předmět:	biology 010405 organic chemistry Diazomethane Ether Plant Science General Chemistry Methylation biology.organism_classification 01 natural sciences Medicinal chemistry General Biochemistry Genetics and Molecular Biology 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Tetra Quercetin Two-dimensional nuclear magnetic resonance spectroscopy Heteronuclear single quantum coherence spectroscopy
Zdroj:	Chemistry of Natural Compounds. 56:837-841
ISSN:	1573-8388 0009-3130
DOI:	10.1007/s10600-020-03164-2
Popis:	The tetra-O-methyl ether of quercetin (QU) 3 (54%), 3,7,4′-tri-O-methyl ether 4 (30%), and a previously unreported 3,7,3-tri-O-methyl ether of QU 5 (7%) were obtained via methylation of QU by an excess of diazomethane in dioxane. Their structures were established using 2D NMR (1H–1H COSY, 1H–1H NOESY, 1H–13C HSQC, 1H–13C HMBC). Tetra-O-methyl ether of QU 3 exhibited pronounced hypoglycemic activity, reduced alloxan-induced hyperglycemia in rats by 44.5% compared to a control, and was 2.7 times more active than QU.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f812c502f6ee7b516c9daf7b32834fc8 https://doi.org/10.1007/s10600-020-03164-2 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.