Ru(ii )/PEG-400 as a highly efficient and recyclable catalytic media for annulation and olefination reactions via C–H bond activation
| Autor: | Subhash L. Yedage, Bhalchandra M. Bhanage |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
PEG 400
Annulation 010405 organic chemistry Isocoumarins chemistry.chemical_element Regioselectivity 010402 general chemistry Cleavage (embryo) 01 natural sciences Pollution Medicinal chemistry 0104 chemical sciences Ruthenium Catalysis chemistry.chemical_compound chemistry Atom economy Environmental Chemistry Organic chemistry |
| Zdroj: | Green Chemistry. 18:5635-5642 |
| ISSN: | 1463-9270 1463-9262 |
| DOI: | 10.1039/c6gc01581f |
| Popis: | In this report synthesis of isoquinolinones, isocoumarins, and N-methyl isoquinolinones and olefination of the Weinreb amides by C–H bond activation using Ru(II)/PEG-400 as green and recyclable media are documented. This developed methodology is capable of the regioselective and stereoselctive construction of new C–C, C–O and C–N bonds by the one step cleavage of C–H, N–H, O–H and N–O bonds. This method is environmentally benign due to its peculiar characteristics such as (i) high atom economy, (ii) reuse of an expensive ruthenium based homogeneous catalytic system, (iii) mild reaction conditions with a simple extraction process and, (iv) importantly, all the systems derived from this protocol being scalable up to the gram level. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|