The Role of a PDGF-Activated Nonselective Cation Channel in the Proliferative Response
| Autor: | A. M. Frace, F. Jung, J. Jay Gargus |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
biology
Chemistry Somatic cell Niflumic acid Mutant chemistry.chemical_element Cell cycle Calcium Phenotype nervous system diseases Cell biology Flufenamic acid nervous system medicine biology.protein biological phenomena cell phenomena and immunity reproductive and urinary physiology Platelet-derived growth factor receptor medicine.drug |
| Zdroj: | Nonselective Cation Channels ISBN: 9783034873291 |
| DOI: | 10.1007/978-3-0348-7327-7_23 |
| Popis: | Murine fibroblasts have a 28 pS calcium- and voltage-insensitive NSC that becomes quiescent at G0 arrest and is rapidly and specifically activated by PDGF. Activation is produced by the discrete loss of long channel closures. The NSC can be rapidly and reversibly blocked with the NSAID flufenamic acid, through a prostaglandin-independent mechanism. The cell cycle (not viability) is blocked concomitantly with NSC block. A somatic cell mutant with altered NSC conductance has been isolated and used to clone the genomic locus of the channel. The mutant growth phenotype adds further support to the participation of NSC conductance in cell cycle control. |
| Databáze: | OpenAIRE |
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