| Autor: |
Mostafa G. Aly, Ahmad B Ahmad, Walaa H. Ibrahim, Heba S Galal, Noha G Sayed, Muhammad H Al-Maghraby |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Journal of The Egyptian Society of Nephrology and Transplantation. 19:19 |
| ISSN: |
1110-9165 |
| DOI: |
10.4103/jesnt.jesnt_23_18 |
| Popis: |
Background An immune-mediated process has been postulated to be involved in the pathogenesis of diabetic nephropathy (DN). Regulatory T-cells (Tregs) mediate self-tolerance and allogeneic tolerance and alteration in its expression was supposed to mediate the development of type 2 DN. We are interested in studying the expression of Treg cells in type 2 DN patients. Patients and methods We conducted a cross-sectional study carried out on 25 type 2 DN patients and 23 nondiabetic control patients. Demographic data were recorded in predefined data sheets. Blood samples for laboratory variables were collected and measured using the standard methods. Flow cytometry analysis was used to assess the phenotype and function of Treg cells from blood samples. Results In the current study, DN patients had a statistically significant higher Treg expression (P=0.038). There were insignificant associations between Treg cells and both proteinuria and duration of diabetes mellitus (P>0.05). Although univariate analysis showed that absolute Treg cell count and duration of diabetes were independent predictors of estimated glomerular filtration rate (P=0.028, 0.039, respectively), multivariate analysis showed that only the absolute Treg cell count was an independent predictor of estimated glomerular filtration rate with a just borderline statistical significance (P=0.048). Conclusion The current study did not support the immunological base of DN and we recommend testing the expression of other T-cell subtypes and cytokines in type 2 DN patients to be more confident about this thinking. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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