Vitamin D endocrine system and bone tissue mineral metabolism in rats with adjuvant arthritis: Effect of 1,25-dihydroxyvitamin D3
| Autor: | Sergeev In, Morozova Na, Korsova Tl, Spirichev Vb, Poznanskaia Aa, Bogoslovskiĭ Na |
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| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Bone density business.industry Osteoporosis chemistry.chemical_element General Medicine Calcium medicine.disease Bone tissue General Biochemistry Genetics and Molecular Biology medicine.anatomical_structure Endocrinology chemistry Internal medicine polycyclic compounds medicine Vitamin D and neurology Endocrine system Polyarthritis business Receptor |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 114:1662-1665 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf00837666 |
| Popis: | Adjuvant arthritis was induced in male rats by injecting bacillus Calmette-Guerin in mineral oil in a hindpaw. A decrease in bone density, calcium and phosphorus content due to polyarthritis was found in the tibia of the noninjected hind leg. Arthritic rats demonstrated serum 1,25-dihydroxyvitamin D deficiency along with constant level of 25-hydroxyvitamin D. The disease caused a significant expression of 1,25-dihydroxyvitamin D3 receptors in lymphocytes. Arthritic rats were treated with 1,25-dihydroxyvitamin D3 (0.15 mg/kg/day orally) for 35 days. The treatment prevented the development of osteoporosis and a decrease of 1,25-dihydroxyvitamin D levels as well as reduced the expression of 1,25-dihydroxyvitamin D receptors in lymphocytes. |
| Databáze: | OpenAIRE |
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