| Popis: |
In the liver carboxylesterase activity is shared between several isoenzymes which hydrolyse a wide variety of substrates, including therapeutic drugs and xenobiotics. Carboxylesterases act also, in vitro, on endogenous lipid substrates, but the physiological meaning of their action on these compounds is still unclear [1, 2]. Most liver carboxylesterases reside in the lumen of the endoplasmic reticulum (ER) where they are either free, or loosely bound to the inner surface of the membrane [3]. |
