| Autor: |
W. Feichtinger, A. Obruca, Heinz Strohmer, E. Krampl |
| Rok vydání: |
1994 |
| Předmět: |
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| Zdroj: |
Gynecology and Obstetrics Urology ISBN: 9783540582274 |
| Popis: |
Many embryo transfers after in vitro fertilization may fail secondary to expulsion of the embryos from the uterus. Approximately 5%–8% of resulting pregnancies after embryo transfer are ectopic. It was the aim of our study to find a technique to avoid ectopic pregnancies and to improve pregnancy rate. We used a two-component fibrin sealant which also contains a fibrinolysis inhibitor (aprotinin) in various concentrations. After gaining experience in mouse embryos we used it in human embryo transfer with great success. The results of a pilot study encouraged us to perform a prospective randomized study on 546 patients (270 with fibrin sealant, 276 conventional embryo transfers). There were 47 (17.03%) orthotopic pregnancies and 6 (2.17%) ectopic pregnancies in the control group, whereas there were 51 (18.89%) intrauterine and no ectopic pregnancies in the treatment group. The difference in ectopic pregnancies was statistically significant (p ‹ 0.05). Regarding aprotinin concentration, there was a trend towards better results with 100–150 kIU (28.5% clinical pregnancies) in comparison to 250–300 kIU (19.23%) or no aprotinin (20.41%) (not significant). Further improvements of the technique may raise the pregnancy rate when fibrin sealant is used. As was shown in our prospective randomized study, ectopic pregnancy may be completely avoided. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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