Prognostic significance of β2-adrenergic receptor expression in patients with surgically resected colorectal cancer
| Autor: | Chika Katayama, Naoya Ozawa, Kyoichi Kaira, Takashi Yao, Yoko Motegi, Hiroshi Saeki, Tetsunari Oyama, Hiroomi Ogawa, Kunihiko Suga, Ryuji Kato, Katsuya Osone, Takayuki Asao, Takahiro Takada, Akira Shimizu, Ryo Takahashi, Takehiko Yokobori, Ken Shirabe |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Univariate analysis Colorectal cancer business.industry Perineural invasion Hematology General Medicine medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Lymphatic system Surgical oncology 030220 oncology & carcinogenesis Internal medicine medicine Immunohistochemistry Surgery In patient Receptor business |
| Zdroj: | International Journal of Clinical Oncology. 25:1137-1144 |
| ISSN: | 1437-7772 1341-9625 |
| Popis: | The β2-adrenergic receptor (β2AR) is highly expressed in various human cancers. The prognostic significance of its expression in patients with colorectal cancer (CRC) remains unclear. The aim of this study was to assess the prognostic role of β2AR expression in patients with surgically resected CRC. One hundred and forty-seven patients with surgically resected CRC were examined using immunohistochemistry. The expression of β2AR was assessed in the specimens of resected primary tumors. β2AR was expressed in 52.3% of the patients’ tumors. β2AR expression was significantly associated with T factor, N factor, and tumor cell proliferation (Ki-67 labeling index). Univariate analysis demonstrated that T factor, N factor, tumor stage, lymphatic permeation, vascular invasion, perineural invasion, β2AR expression, and Ki-67 labeling index were significant prognostic factors for worse disease-free survival (DFS); all but T factor were also significant predictors for worse overall survival (OS). Multivariate analysis confirmed that expression of β2AR was a significant prognostic marker for predicting worse DFS and OS. β2AR expression was identified as a significant independent prognostic factor in patients with surgically resected CRC. |
| Databáze: | OpenAIRE |
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