Síndrome de reacción a drogas con eosinofilia y síntomas sistémicos asociado a herpesvirus humano 6. Caso pediátrico tratado con ciclosporina y corticoides
| Autor: | Yerco Mairon Goldman Pérez, Javier Arellano, Stephanie Saavedra Portales, Yamile Corredoira, Margarita Sánchez Chacón, Elena Kakarieka |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
biology medicine.diagnostic_test business.industry medicine.disease biology.organism_classification Gastroenterology Pediatric drug Prednisone Internal medicine Pediatrics Perinatology and Child Health Skin biopsy medicine biology.protein Eosinophilia Human herpesvirus 6 Antibody medicine.symptom business Adverse drug reaction Human herpesvirus medicine.drug |
| Zdroj: | Archivos Argentinos de Pediatria. 119 |
| ISSN: | 0325-0075 |
| Popis: | Drug reaction with eosinophilia and systemic symptoms syndrome associated with human herpesvirus 6. A pediatric case treated with cyclosporine and corticosteroids elevated C-reactive protein, and abnormal liver tests. The skin biopsy was compatible with an adverse drug reaction. Treatment with systemic corticosteroids and intravenous immunoglobulin had no response. Polymerase chain reaction for human herpesvirus type 6 was positive, and cyclosporine plus prednisone was started with a good response. There is little evidence for the use of cyclosporine in adults when systemic corticosteroids are ineffective. This is the first report of pediatric drug reaction with eosinophilia and systemic symptoms treated with cyclosporine, which could be an effective alternative or an adjunct to systemic corticosteroid therapy unresponsive to conventional treatments. |
| Databáze: | OpenAIRE |
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