MiRNA-199a-3p: A potential circulating diagnostic biomarker for early gastric cancer

Autor:	Qu Cai, Jian Fang Li, Chen Li, Zheng Gang Zhu, Bing Ya Liu, Min Yan, Qing Qing Qiu
Rok vydání:	2013
Předmět:	medicine.medical_specialty Pathology business.industry General Medicine Gastroenterology Early Gastric Cancer Circulating biomarkers Oncology Internal medicine microRNA medicine Biomarker (medicine) Diagnostic biomarker Surgery business
Zdroj:	Journal of Surgical Oncology. 108:89-92
ISSN:	0022-4790
DOI:	10.1002/jso.23358
Popis:	Background Tumor-associated miRNAs have been detected in serum or plasma. We investigated whether plasma miRNA-199a-3p could be a potential circulating biomarker for early gastric cancer (EGC). Methods By using real-time qRT-PCR, the expression of miRNA-199a-3p were compared between these pre-operative plasmas from 30 EGC patients and 70 healthy controls, and between these pre-operative and post-operative plasmas. Further validation was on an independent set of plasmas from 50 EGC patients. Results The expression of miRNA-199a-3p (47.5 ± 6.5) in plasma in EGC patients was significantly higher than that from healthy controls (13.9 ± 2.7, P
Databáze:	OpenAIRE
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