Asymmetric synthesis of α,α-diaryl and α-aryl-α-heteroaryl alkylamines by organometallic additions to N-tert- butanesulfinyl ketimines

Autor:	Anthony W. Shaw, S. Jane Desolms
Rok vydání:	2001
Předmět:	chemistry.chemical_classification chemistry.chemical_compound chemistry Yield (chemistry) Aryl Organic Chemistry Drug Discovery Imine Enantioselective synthesis Organic chemistry Counterion Selectivity Biochemistry
Zdroj:	Tetrahedron Letters. 42:7173-7176
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(01)01513-1
Popis:	Organometallic addition to tert -butanesufinyl ketimines derived from diaryl and aryl-heteroaryl ketones provided the corresponding α,α-diaryl and α-aryl-α-heteroaryl alkylamines in good yield with high diastereoselectivity. In many cases, imine facial selectivity is reversed on changing the organometallic counterion.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f7d51886c659268f673a1ea27879d928 https://doi.org/10.1016/s0040-4039(01)01513-1 Zobrazit plný text záznamu Full Text from ScienceDirect