| Popis: |
STUDIES carried out in our laboratory over the past three years have been directed toward determining the factors which influence cataract susceptibility in the chick embryo. The lesion was experimentally produced by injecting, 2,4-dinitrophenol (DNP) into the incubating egg (Feldman et al., 1958). The embryo was found to be very susceptible to the DNP-induced cataracts after eight to twelve days of incubation, but increasingly resistant thereafter (Feldman et al., 1959). Studies were then undertaken to determine whether any biochemical changes occurred which could be related to DNP resistance. The embryonic lipids were among the first parameters to be measured and were found to exhibit striking changes in concentration which occurred at the same time that DNP resistance began (Feldman and Doyle, 1961). The neutral lipids increased from 37% of the total lipid on the eleventh day to 49% of the total lipid on the twelfth day of incubation. The neutral … |
