Lecithin-based modified soft agglomerate composite microparticles for inhalable montelukast: Development, tolerability and pharmacodynamic activity
| Autor: | Nahed D. Mortada, Roxane Abdel-Gawad, Rihab Osman, Gehanne A.S. Awad |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
food.ingredient
Materials science General Chemical Engineering 02 engineering and technology 021001 nanoscience & nanotechnology Lecithin Dry-powder inhaler food 020401 chemical engineering Chemical engineering Agglomerate Spray drying medicine Particle Mannitol 0204 chemical engineering 0210 nano-technology Aerosolization Montelukast medicine.drug |
| Zdroj: | Powder Technology. 360:1167-1176 |
| ISSN: | 0032-5910 |
| Popis: | In this work, montelukast (MTK) was incorporated in inhalable soft agglomerates (SA) exhibiting inherent characteristics for deep lung deposition while expressing good flowability and enhanced shelf-life stability. Mannitol and ovalbumin were used as particle shapers and lecithin as binder during microparticles (MPs) preparation by spray drying. The spontaneously agglomerated MPs with an adhesive surface were designed to deagglomerate under the effect of aerosolization with selected dry powder inhaler device, achieving satisfactory lung deposition. A pharmacodynamic study was also undertaken to evaluate MTK-SA effectiveness in asthmatic rats. Optimized SA showed agglomerated small MPs capable of dispersing into individual particles under pressures exceeding 1Bar. They exhibited high respirable fraction of >54% and were able to release MTK in |
| Databáze: | OpenAIRE |
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