Eine neue synthese von vinblastin-derivaten v. konzept und untersuchungen zur synthese von 20'-desethyl-20'-desoxy- c'-homovinblastin—octahydro-3H-azecino[5,4-b]inidol-derivate

Autor:	Gottfried Schill, Hans Fritz, Claus Ulrich Priester, Udo Frank Windhövel
Rok vydání:	1990
Předmět:	Tryptamine chemistry.chemical_compound chemistry Bicyclic molecule Stereochemistry Organic Chemistry Drug Discovery Lactam Biochemistry Derivative (chemistry)
Zdroj:	Tetrahedron. 46:1211-1220
ISSN:	0040-4020
Popis:	Zusammenfassung A concept for the synthesis of C'- homovinblastine derivative 1 is presented in which the azecinoindole derivative 3 and the bicyclic lactam 5 are key intermediates. Starting from tryptamine, the synthesis of these two intermediates is described. In addition, the C-homocleavamine derivative 14 is synthesized.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f7c49e976dac912373f98a14d3750060 https://doi.org/10.1016/s0040-4020(01)86686-2 Zobrazit plný text záznamu