| Popis: |
Wound healing has always been a fascinating phenomenon for physicians and surgeons. Wounds usually close by forming new granulation tissue, contracting, and re-epithelializing. Before granulation begins, polymor-phonuclear leukocytes (PMNs) and monocytes/macrophages (MCs) are chemotactically attracted to sites of injury. Upon contact with various stimuli in the wound including bioactive lipids, complement components, certain cytokines, e.g., tumor necrosis factor-α (TNF-α) [1], granulocyte/ monocyte-colony stimulating factor (GM-CSF), interferon-γ (IFN-γ), and interleukin-8, and particles such as microorganisms, phagocytes respond by a respiratory burst consisting of a markedly enhanced uptake of oxygen, activation of the hexose monophosphate shunt, and generation of oxygen intermediates comprising Superoxide anion, hydrogen peroxide, hydroxyl radical and singlet oxygen [1, 2]. These compounds are able to kill microorganisms and to destroy tissue resulting in wound decontamination and wound debridement (summarized in [3]). |
