Expression of neural cell adhesion molecule in renal cell carcinoma
| Autor: | Bojan Čegar, Sanja Cirovic, Jasmina Markovic-Lipkovski, Jelena Vjestica, Aleksandar Vuksanovic, Miodrag D Lazić, Dragan B Mitrović, Dusko M Dundjerović, Cane Tulic, Martina M Stojanović |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
0303 health sciences
medicine.diagnostic_test business.industry Cell migration General Medicine urologic and male genital diseases medicine.disease Immunofluorescence female genital diseases and pregnancy complications 03 medical and health sciences 0302 clinical medicine nervous system Cell culture Renal cell carcinoma 030220 oncology & carcinogenesis Immunology Cancer research Carcinoma medicine Immunohistochemistry Neural cell adhesion molecule business neoplasms Clear cell 030304 developmental biology |
| Zdroj: | Acta chirurgica Iugoslavica. 59:39-44 |
| ISSN: | 2406-0887 0354-950X |
| Popis: | Neural cell adhesion molecule (NCAM) is important for cell migration and it could be expressed in some renal cell carcinoma (RCC). In recent decades, the incidence of RCC has been steadily rising by 2-4% each year. In this study NCAM expression and correlation with nuclear grade in different RCC were analyzed. We analyzed NCAM expression on 7 different RCC cell lines and 32 different RCC by immunohistochemistry, immunofluorescence, Western blot and FACS analysis. NCAM expression is detected in 6 cell lines and 16 RCC cases. NCAM-140 kDa isoform is expressed in different RCC and RCC cell lines. NCAM expression in non-invasive clear cell RCC is lower than in clear cell RCC with high nuclear grade. Expression of NCAM is not exclusive for specific RCC type, so NCAM can not be used as a specific diagnostic marker for RCC. NCAM expression is in correlation with nuclear grade in clear cell RCC, suggesting that NCAM expression is involved in aggressive behavior and metastatic potential in RCC. |
| Databáze: | OpenAIRE |
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