Reactivity of neuroglia in guinea pigs sensitized by Mycobacterium tuberculosis
| Autor: | L. I. Brusina, A. Kh. Kanchurin |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Pathology
medicine.medical_specialty biology Encephalomyelitis General Medicine biology.organism_classification medicine.disease General Biochemistry Genetics and Molecular Biology Mycobacterium tuberculosis Tissue culture Blood serum medicine.anatomical_structure Antigen Immunology medicine Neuroglia Reactivity (chemistry) sense organs Sensitization |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 80:1087-1090 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf00799899 |
| Popis: | In guinea pigs with experimental allergic encephalomyelitis (EAE) induced by sensitization withMycobacteriumtuberculosis cells mixed with petrolatum and Arlacel the reactivity of the glia was shown to change regularly depending on the stage and severity of the pathological process. Changes in reactivity determined by inhibition of glial migration in tissue culture were specific with respect to antigens from nerve tissue. The study of the mechanism of this phenomenon showed that similar changes in reactivity can be induced in a culture of glial cells from intact animals if blood serum or regional lymph gland cells taken from actively sensitized guinea pigs are added. It cannot yet be concluded from the available results that changes in reactivity of the glia to products of brain tissue destruction in guinea pigs with EAE are completely attributable to the action of humoral or cellular elements which penetrate into the CNS from the bloodstream or lymphatic tissue. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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