False negative scintigraphy with 99mTc-sestamibi in parathyroid carcinoma with associated brown tumors. Contributions of 18F-FDG-PET/CT
| Autor: | H. Palacios Gerona, M. Moreno Caballero, M. Navarro-Pelayo Láinez, J.M. Llamas Elvira, C. Ramos Font, M.A. Muros de Fuentes, A. Santiago Chinchilla |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Hyperparathyroidism Pathology endocrine system diseases medicine.diagnostic_test Parathyroid neoplasm business.industry Immunology Osteitis fibrosa cystica Parathyroid hormone Scintigraphy medicine.disease Bone remodeling Parathyroid carcinoma medicine Immunology and Allergy Radiology Differential diagnosis business |
| Zdroj: | Revista Española de Medicina Nuclear (English Edition). 30:174-179 |
| ISSN: | 1578-200X |
| DOI: | 10.1016/s1578-200x(11)70024-9 |
| Popis: | Parathyroid carcinoma (PTC) is a rare malignant disease that is usually hyperfunctioning, which produces an excess of parathyroid hormone. Hyperparathyroidism causes bone metabolism disorders, as osteopenia and sometimes brown tumors. Brown tumors are benign but locally aggressive bone lesions, whose differential diagnosis with metastases or other primary malignancies may be complicated. (99m)Tc-Sestamibi scan is the usual procedure for the detection of parathyroid pathology, with a sensitivity of 85-100% and specificity close to 100% in parathyroid adenomas, it having similar percentages in the detection of PTC. We present the case of a patient diagnosed of a malignant hyperparathyroidism associated with bone lesions in which the (99m)Tc-Sestamibi scan showed a false negative result in the detection of parathyroid condition. However, (18)F-FDG-PET/CT detected the PTC and helped in the differential diagnosis of associated bone lesions, which were finally confirmed as brown tumors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|