| Autor: |
Ziwen Wang, Guo Pengbin, Lanya Zhang, Shuang Yan, Weihui Zhuang, Zeliang Hu, Qingmin Wang, Yan Xiong |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Journal of Heterocyclic Chemistry. 54:121-124 |
| ISSN: |
0022-152X |
| DOI: |
10.1002/jhet.2549 |
| Popis: |
An efficient method for the preparation of alkaloids polycarpine and polycarpaurines A and C via microwave-assisted three-step one-pot reaction as the key step has been developed. This is the first report about the synthesis of polycarpaurines A and C. Starting from commercially available p-methoxybenzaldehyde, polycarpine and polycarpaurine A were obtained over seven steps with 40 and 24 % overall yield, respectively. Polycarpine could convert to polycarpaurine C in 72% yield in the presence of NaHSO3. The structure of polycarpine and polycarpaurines A and C was confirmed by 1H NMR, 13C NMR, and HRMS. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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