G-CSF Producing Maxillary Sinus Cancer. A Case Report

Autor:	Hiroshi Nishino, Mamoru Miyata, Mamoru Morita, Takeharu Kanazawa, Kazuhiro Ishikawa, Ken Kitamura
Rok vydání:	1999
Předmět:	Pathology medicine.medical_specialty Lung business.industry medicine.medical_treatment Granulocytosis Cancer medicine.disease Radiation therapy Maxillary Sinus Cancer medicine.anatomical_structure Otorhinolaryngology Maxilla Cancer cell medicine Lymph business
Zdroj:	Practica Oto-Rhino-Laryngologica. 92:987-992
ISSN:	1884-4545 0032-6313
DOI:	10.5631/jibirin.92.987
Popis:	A 64-year-old man with well-differentiated squamous cell carcinoma of the maxilla who presented with high levels of granulocyte-colony stimulating factor (G-CSF) is described. The extent of the tumor was staged as T4N1M0. Regional chemotherapy, radiotherapy and resection of the tumor were performed. The patient died of local recurrence and lung metastasis about four months after admission. During his clinical course, a peripheral blood analysis demonstrated marked granulocytosis and high G-CSF activity. G-CSF producing cancer cells were immunohistologically observed in the primary lesion and metastatic lymph nodes. Therefore, he was diagnosed with G-CSF producing maxillary cancer. The cancer tissue from this patient was transplanted into nude mice, and one of these mice demonstrated distant metastasis to the lung.
Databáze:	OpenAIRE
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