Preliminary investigations of anti-cancer properties of Myrmecodia Pendens on human oral cancer HSC-3 cell lines
| Autor: | Nining Irfanita, N.A. Aziz, Widya Lestari, Shah Eddie, Solachuddin Jauhari Arief Ichwan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
010302 applied physics
medicine.diagnostic_test biology Chemistry Cancer 02 engineering and technology 021001 nanoscience & nanotechnology medicine.disease biology.organism_classification 01 natural sciences Flow cytometry HeLa Cell culture Apoptosis 0103 physical sciences Cancer cell medicine Cancer research MTT assay 0210 nano-technology Cytotoxicity |
| Zdroj: | Materials Today: Proceedings. 16:2197-2203 |
| ISSN: | 2214-7853 |
| DOI: | 10.1016/j.matpr.2019.06.110 |
| Popis: | Myrmecodia pendens (M. pendens) or also known as Sarang semut is an epiphytic plant which might have potential as a new source of alternative therapeutic agent. Recently, it is reported that M. pendens can inhibit the proliferation of HeLa and MCM-B2 cell lines. We report here for the first time the anti-cancer potential of M. pendens on oral cancer cells derived from human oral cavity, HSC-3 cell lines. MTT assay results showed that M. pendens crude extract markedly induced cytotoxicity on HSC-3 cell lines after 24 h (IC50 = 5 mg/mL) and 48 h (IC50 = 3 mg/ml). The apoptotic activity induced by M. pendens was detected in HSC-3 cell lines by flow cytometry within 24 h. These results suggest that M. pendens may be a potential candidate for oral cancer treatment. |
| Databáze: | OpenAIRE |
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