Estimation and Extrapolation of Tumor Probabilities from a Mouse Bioassay with Survival/Sacrifice Components

Autor:	John H. Farmer, Ralph L. Kodell, David W. Gaylor
Rok vydání:	1982
Předmět:	Mouse bioassay Nonparametric estimator Physiology (medical) Statistics Extrapolation Probability distribution Bioassay Effective sample size Safety Risk Reliability and Quality Mathematics
Zdroj:	Risk Analysis. 2:27-34
ISSN:	1539-6924 0272-4332
DOI:	10.1111/j.1539-6924.1982.tb01400.x
Popis:	A nonparametric estimator of the probability distribution of time-to-tumor is incorporated into an algorithm for calculating linearly extrapolated dosage limits from an animal carcino-genesis bioassay. The procedure is illustrated with tumor data from a mouse bioassay with 2-acetylaminofluorene. Extrapolated dosage limits for an excess risk of 10-6 differ by only a factor of 2 across the six replicates of the experiment.
Databáze:	OpenAIRE
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