Structural and Biological Basis of Small Molecule Inhibition of Escherichia coli LpxD Acyltransferase Essential for Lipopolysaccharide Biosynthesis
| Autor: | Min Li, Micah Steffek, Wooseok Han, Chi-Min Ho, J. de Vicente, Xiaolei Ma, Yipin Lu, Charles Wartchow, Tsuyoshi Uehara, S. Ramurthy, B. Chie Leon, Steven Shia, Ramadevi Prathapam |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification biology Chemistry 030106 microbiology medicine.disease_cause biology.organism_classification Small molecule 03 medical and health sciences 030104 developmental biology Infectious Diseases Enzyme Biochemistry Acyltransferase medicine Transferase lipids (amino acids peptides and proteins) Surface plasmon resonance Lipopolysaccharide Biosynthesis Escherichia coli Bacteria |
| Zdroj: | ACS Infectious Diseases. 6:1480-1489 |
| ISSN: | 2373-8227 |
| DOI: | 10.1021/acsinfecdis.9b00127 |
| Popis: | LpxD, acyl-ACP-dependent N-acyltransferase, is the third enzyme of lipid A biosynthesis in Gram-negative bacteria. A recent probe-based screen identified several compounds, including 6359-0284 (com... |
| Databáze: | OpenAIRE |
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