Automatic Selection of Mobile Phases. VII. Thin‐Layer Chromatography on Silica and Alumina of 11,12‐Disubstituted trans/cis‐11,12‐Dihydro‐6H‐dibenzo[c,h]chromen‐6‐ones
| Autor: | Ivan Svinyarov, Mariana D. Palamareva, Milen G. Bogdanov, Ch. E. Palamarev, Yavor Mitrev |
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| Rok vydání: | 2007 |
| Předmět: |
chemistry.chemical_classification
Chromatography Chemistry Silica gel Clinical Biochemistry Pharmaceutical Science Biochemistry High-performance liquid chromatography Thin-layer chromatography Analytical Chemistry Solvent chemistry.chemical_compound Stationary phase Phase composition Cis–trans isomerism Lactone |
| Zdroj: | Journal of Liquid Chromatography & Related Technologies. 30:2155-2169 |
| ISSN: | 1520-572X 1082-6076 |
| DOI: | 10.1080/10826070701451498 |
| Popis: | Fifteen title compounds with four fused rings and two varying substituents were used to further specify the scope and limitation of a theoretical approach (the Snyder theory and LSChrom software) for selection of mobile phases avoiding any trial and error experiments. Based on the structure of the compounds, the theoretical treatment predicted values of strength ϵ of suitable mobile phases for TLC, namely 0.311 for silica and 0.446 for alumina. Sixteen specific mobile phases with such or close values of ϵ were arbitrarily selected from lists prepared by complex calculations. They were used to perform TLC. The data obtained showed that the retentions in all 256 measurements done were above the origin and below the solvent front. Thus, a good agreement between the theoretical and experimental data was established, thus proving a successful application of the approach. The retentions of all compounds and separation of one cis/trans pair depended on the stationary phase, ϵ, and the tuning parameters ... |
| Databáze: | OpenAIRE |
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