Simultaneous Determination of Diclofenac Sodium and Rabeprazole Sodium in Bulk and Pharmaceutical Dosage Form by LC

Autor:	Godge Rahul, Bhat Leena, Damle Mrinalini, Vora Asfak
Rok vydání:	2007
Předmět:	Detection limit Chromatography Chemistry Organic Chemistry Clinical Biochemistry Indapamide Rabeprazole Diclofenac Sodium Biochemistry High-performance liquid chromatography Dosage form Analytical Chemistry medicine Rabeprazole Sodium Quantitative analysis (chemistry) medicine.drug
Zdroj:	Chromatographia. 66:941-943
ISSN:	1612-1112 0009-5893
Popis:	A simple, selective, rapid, precise and accurate reverse phase high pressure liquid chromatographic method has been developed for the simultaneous estimation of diclofenac sodium and rabeprazole sodium from pharmaceutical formulations. The method was developed using a HiQ SiL C18 (250 mm × 4.6 mm i.d.) column with a mobile phase consisting of methanol:water, (80:20 v/v), at a flow rate of 1.25 mL min−1. Detection was carried out at 284 nm. Indapamide was used as an internal standard. The developed method was validated for linearity, accuracy, precision, limit of detection and limit of quantitation. The proposed method can be used for the estimation of these drugs in combined dosage forms.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f7763230a8cc4cf90babf9a3445c5123 https://doi.org/10.1365/s10337-007-0428-y Zobrazit plný text záznamu Full text from SpringerLink