Palladium-catalyzed direct reductive cross-coupling of aryltrimethylammonium salts with aryl bromides

Autor: Na-Na Ma, Chen Zhang, Weidong Rao, Xiaocong Zhou, Zhi-Liang Shen, Chuanji Shen, Zi-Lun Yu, Xue-Qiang Chu
Rok vydání: 2021
Předmět:
Zdroj: Organic Chemistry Frontiers. 8:4865-4870
ISSN: 2052-4129
DOI: 10.1039/d1qo00759a
Popis: An efficient palladium-catalyzed direct reductive cross-coupling of aryltrimethylammonium salts with aryl bromides was developed. The reactions proceeded smoothly in the presence of a palladium catalyst, magnesium turnings, LiCl, and TMEDA in THF at room temperature, leading to the corresponding biaryl compounds in moderate to good yields with reasonable functional group tolerance. The one-pot reaction using cheap and readily available aryl bromide as a coupling partner is simple to handle, thereby avoiding the use of pre-prepared organometallic reagents.
Databáze: OpenAIRE