Immunological characteristics of the tumor microenvironment of breast cancer and their utilization as prognostic factor and treatment: a review / Características imunológicas do microambiente tumoral do câncer de mama e sua utilização como fator prognóstico e tratamento: uma revisão

Autor: Julliano Matheus de Lima Maux, Andressa de Souza Cavalcante, Giwellington Silva Albuquerque, Ana Karina Brizeno Ferreira Lopes, Jacinto da Costa Silva Neto, Denise de Queiroga Nascimento
Rok vydání: 2021
Předmět:
Zdroj: Brazilian Journal of Development. 7:111406-11426
ISSN: 2525-8761
Popis: Globally, breast cancer is the most diagnosed neoplasm in women. In some countries, it’s consolidated as the type of neoplasm that causes the most deaths, being responsible for premature deaths. The molecular classification of cancer allows specific treatment for each patient; however, some types have resistance that results in an unfavorable prognosis. For this reason, researches are being developed in order to use the complexity of the immune system as a tool to combat the heterogeneity of breast cancer. Lately, studies have evaluated the leukocyte infiltrates present in the tumor microenvironment have become a promising field in therapeutic innovation, which is based on the cellular composition of the neoplastic environment of cancers with poor prognosis, whose immunotherapeutic action is specific to each molecular subtype. The expression of immune cells in the tumor microenvironment has potential for oncological parameters that can help in the treatment and also to define the prognosis.
Databáze: OpenAIRE