Comparative Evaluation of Wound Healing Effect of Cord Blood Low Molecular Weight Fraction (Below 5 kDa) and Actovegin Drug in Skin Cryolesions

Autor:	Olga Gorina, Oleksandr K. Gulevsky, Nataliia Moisieieva, Yuliya S. Akhatova
Rok vydání:	2021
Předmět:	Drug business.industry media_common.quotation_subject Cord blood Biophysics Medicine (miscellaneous) Medicine Pharmacology Wound healing business Comparative evaluation media_common
Zdroj:	Problems of Cryobiology and Cryomedicine. 31:116-126
ISSN:	2518-7376 2307-6143
DOI:	10.15407/cryo31.02.116
Popis:	This paper presents the results of comparative studies of the impact of the low molecular weight (below 5 kDa) cattle cord blood fraction (CBF) and the comparator drug Actovegin on tissue regeneration after skin cryoablation in rats. Here, a local contact cryoexposure was shown to result not only in destruction of all skin layers, but secondary ischemic damage to deeper and adjacent tissues as well. The use of an injection solution of CBF as a therapy for simulated cryolesion proved its pronounced wound healing effect, manifested in accelerated reparation, improved trophicity in an injured area due to hypervascularization and prevention of sclerotic processes. The introduction of CBF and Actovegin to rats accelerated the normalization of clinical blood parameters (RBC and WBC counts, alkaline phosphatase activity) in shorter terms as compared with the control. The obtained effect may be compared with Actovegin action.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f754abce394279757593a60300969706 https://doi.org/10.15407/cryo31.02.116 Zobrazit plný text záznamu