4. Does small fiber pathology in PD change over time?

Autor:	Annamaria Stancanelli, A.M. Saltalamacchia, I. Borreca, Bernardo Lanzillo, Maria Nolano, F. Lullo, Vincenzo Provitera, Giuseppe Caporaso, G. Piscosquito, Lucia Santoro
Rok vydání:	2017
Předmět:	Change over time Pathology medicine.medical_specialty business.industry Disease duration Quantitative sensory testing Nerve fiber Disease Sensory Systems Patient care Disease course Sudomotor medicine.anatomical_structure Neurology Physiology (medical) medicine Neurology (clinical) business
Zdroj:	Clinical Neurophysiology. 128:e416
ISSN:	1388-2457
Popis:	Small fiber pathology is part of the clinical picture of PD. Cross-sectional studies have shown no correlation between intraepidermal nerve fiber (IENF) density and patient disease duration and severity. However, it is not known whether IENF density changes over time. We aimed to assess the progression of small fiber pathology in PD patients along the disease course. We assessed epidermal innervation at time 0 and after 1–9 years (mean 3.5) in 17 PD patients (M/F = 11/6, age = 64.4 ± 15.3) leg on punch biopsies. Patients were assessed in a rehabilitative setting. They underwent yearly 30-days hospitalizations and were trained to continue a home-personalized program of physical exercises between successive evaluations. Quantitative sensory testing and sudomotor assessment were also performed. Overall, no difference ( p = 0.12) between the first and the last IENF density (8.7 ± 4.0 vs. 10.3 ± 4.9) assessment was found. However, the IENF density variation correlated with the disease duration ( r = 0.71; p The small fiber pathology associated to PD can improve to some extent by optimizing patient care, at least in the first stages of disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f7526c4ca571a5eeed61c966d879bb78 https://doi.org/10.1016/j.clinph.2017.09.011 Zobrazit plný text záznamu Full Text from ScienceDirect