The development of neutralizing antibodies in a patient receiving subcutaneous recombinant and natural interleukin-2

Autor: Jens Atzpodien, Alfred Körfer, Klaus Resch, Pauline Evers, Martin Hadam, Ulrich Pohl, Harald Mohr, Hubert Poliwoda, Marta Szamel, Joseph Knüver-Hopf, Chris R. Franks, Hartmut Kirchner
Rok vydání: 1991
Předmět:
Zdroj: Cancer. 67:1862-1864
ISSN: 1097-0142
0008-543X
DOI: 10.1002/1097-0142(19910401)67:7<1862::aid-cncr2820670708>3.0.co;2-r
Popis: Systemic administration of interleukin-2 (IL-2) in humans may induce antibodies specific to IL-2. The case is reported of a patient with metastatic rectal carcinoma who was treated with long-term subcutaneous IL-2 and a combination of subcutaneous IL-2 and interferon-alpha 2b (IFN-alpha 2b). This patient developed nonneutralizing and neutralizing anti-IL-2 antibodies recognizing both the recombinant and natural cytokine. Detectable serum levels of neutralizing antibodies were accompanied by the inhibition of immune responsiveness to systemic IL-2 in vivo.
Databáze: OpenAIRE