Mutagenic and antimutagenic properties of bemitil

Autor:	Dubovskaia OIu, Bobkov IuG, Seredenin Sb, Durnev Ad
Rok vydání:	1986
Předmět:	Drug medicine.anatomical_structure Cell culture Dominant lethal media_common.quotation_subject medicine General Medicine Bone marrow Biology Molecular biology General Biochemistry Genetics and Molecular Biology Peripheral blood media_common
Zdroj:	Bulletin of Experimental Biology and Medicine. 102:962-965
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf00840006
Popis:	Complex research of the genetic activity of a new 2-mercaptobenzimidazole derivative bemythyl has shown that the drug failed to induce recessive, age-related lethal mutations in drosophila, dominant lethal mutations in germ mammalian cells and chromosomal damage in murine bone marrow cells and human peripheral blood cell cultures. The experiments on mice have demonstrated that therapeutic bemythyl doses caused a two-fold decrease in the level of aberrant cells induced by alkylating agents--fotrin and fopurin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f74cf12af998ae1f2f7937e98a8b54df https://doi.org/10.1007/bf00840006 Zobrazit plný text záznamu Full text from SpringerLink