| Autor: |
null Wajdy Jabbar Majid, null Tayseer Ali Talab, null Muslim Nahi Saeed |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
International Journal of Biological and Pharmaceutical Sciences Archive. 2:055-058 |
| ISSN: |
0799-6616 |
| DOI: |
10.53771/ijbpsa.2021.2.1.0068 |
| Popis: |
Polycystic ovarian syndrome (PCOS) is an endocrine disorder affecting women in child bearing age and is considered the main cause of infertility. This study aims to determine the efficacy of cyproterone 12 mg/ kg and metformin 50 mg/kg as a single oral daily dose for 20 days, in PCOS induced in female rats by estrogen valerate. In untreated group PCOS, the level of serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) was significantly (P< 0.0001) decrease, while estradiol and testosterone levels were increased significantly (P< 0.0001 and P< 0.001 respectively) in comparison with control group. Both cyproterone and metformin significantly increased LH and FSH levels (P< 0.05) compared to the untreated PCOS group. Both cyproterone and metformin reduced the level of estradiol hormone significantly (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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