Structure–Function Insights of Membrane and Soluble Proteins Revealed by Electron Crystallography

Autor: Tina M. Dreaden, Bridgette A. Barry, Ingeborg Schmidt-Krey, Bharanidharan Devarajan
Rok vydání: 2012
Předmět:
Zdroj: Methods in Molecular Biology ISBN: 9781627031752
DOI: 10.1007/978-1-62703-176-9_27
Popis: Electron crystallography is emerging as an important method in solving protein structures. While it has found extensive applications in the understanding of membrane protein structure and function at a wide range of resolutions, from revealing oligomeric arrangements to atomic models, electron crystallography has also provided invaluable information on the soluble α/β-tubulin which could not be obtained by any other method to date. Examples of critical insights from selected structures of membrane proteins as well as α/β-tubulin are described here, demonstrating the vast potential of electron crystallography that is first beginning to unfold.
Databáze: OpenAIRE