Effects of apolipoprotein A-IV genotype on glucose and plasma lipoprotein levels
| Autor: | IA Larson, JM Ordovas, Z Sun, null Barnard, J Lohrmann, G Feussner, S Lamon-Fava, EJ Schaefer |
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| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
education.field_of_study Apolipoprotein B biology Triglyceride Cholesterol Population chemistry.chemical_compound Endocrinology High-density lipoprotein chemistry Low-density lipoprotein Internal medicine Genotype Genetics biology.protein medicine lipids (amino acids peptides and proteins) education Genetics (clinical) Lipoprotein |
| Zdroj: | Clinical Genetics. 61:430-436 |
| ISSN: | 0009-9163 |
| DOI: | 10.1034/j.1399-0004.2002.610606.x |
| Popis: | The effects of apolipoprotein (apo) A-IV genotype on serum glucose, total cholesterol, low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, triglyceride and glucose concentrations were ascertained in a population of 373 men and 361 women with a mean age of about 57 years. Subjects were evaluated at entry into a lifestyle intervention program. Apolipoprotein A-IV genotype variations at residues 347 and 360 were examined, as these mutations affect the sequence of apo A-IV, a major protein constituent of intestinal triglyceride-rich lipoprotein and HDL. With regard to the apo A-IV 360 mutation, 16.4% of the females and 13.4% of the males carried the apo A-IV 2-allele, almost entirely in the heterozygous state. No effect of the apo A-IV 1/2 genotype was observed in either men or women on total cholesterol, LDL cholesterol, HDL cholesterol, triglyceride, the total cholesterol (TC)/HDL ratio, or on A-I, A-IV and apo B levels. This was also the case for the apo A-IV 347 mutation. However, women with the apo A-IV 360 1/2 genotype had significantly (p |
| Databáze: | OpenAIRE |
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