Invitro antimalarial activity, chloroquine potentiating effect and cytotoxicity of alkaloids ofHernandia voyronii Jum. (Hernandiaceae)

Autor:	F. Verdier, Philippe Rasoanaivo, S. Ratsimamanga-Urverg, Herintsoa Rafatro, R. Milijaona, A. Rakoto-Ratsimamanga, J. Le Bras, B. Robijaona, J. Rakotoarimanga
Rok vydání:	1994
Předmět:	Pharmacology biology Alkaloid Biological activity Plasmodium falciparum biology.organism_classification HeLa Chloroquine parasitic diseases Hernandiaceae medicine Hernandia Cytotoxicity medicine.drug
Zdroj:	Phytotherapy Research. 8:18-21
ISSN:	1099-1573 0951-418X
Popis:	Hernandia voyronii is traditionally used as adjuvant to chloroquine in Madagascar. Neutral and basic alkaloidal extracts of this plant were evaluated for their intrinsic in vitro antimalarial activity, cytotoxicity and chloroquine potentiating action against the chloroquine resistant Plasmodium falciparum strain FCM29. Bioassay directed fractionation clearly demonstrated that both the intrinsic antimalarial activity and the chloroquine potentiating action was localized in the polar alkaloidal extract. Moreover, this extract had low cytotoxicity to HeLa cells and L929 fibroblasts. These results support the traditional use of H. voyronii as an antimalarial and adjuvant to chloroquine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f7334339cf8ffe0f8cf959de591bb041 https://doi.org/10.1002/ptr.2650080105 Zobrazit plný text záznamu Plný text