Regeneration of nerve crush injury using adipose-derived stem cells: A multimodal comparison
| Autor: | Daniel F. Kalbermatten, Lucas Degrugillier, Mathias Tremp, Srinivas Madduri, Stefan Schaeren, Dirk J. Schaefer, Lima Sprenger |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Physiology business.industry Regeneration (biology) Adipose tissue medicine.disease Muscle atrophy Lesion 03 medical and health sciences Cellular and Molecular Neuroscience Gastrocnemius muscle 030104 developmental biology 0302 clinical medicine Physiology (medical) Nerve crush Crush injury medicine Neurology (clinical) medicine.symptom Stem cell business 030217 neurology & neurosurgery |
| Zdroj: | Muscle & Nerve. 58:566-572 |
| ISSN: | 0148-639X |
| DOI: | 10.1002/mus.26188 |
| Popis: | Introduction To restore full function following nerve crush injuries is critical but challenging. In an attempt to develop a viable therapy, we evaluated the effect of rat adipose-derived stem cells (rASC) in 2 different settings of a sciatic crush injury model. Methods In the first group, after 14 days of nerve crush injury, rASCs were injected distal to the lesion under ultrasound guidance. In the other group, alleviation of compression through clip removal (CR) was combined with epineural injection of rASCs. Gait analyses, MRI, gastrocnemius muscle weight ratio (MWR), and histomorphometry were performed for outcome analysis. Results CR combined with rASC injection resulted in less muscle atrophy, as evidenced by MWR. These findings are further supported by better functional and anatomical outcomes. Discussion Animals treated with CR and epineural stem cell injection showed enhanced anatomical and functional recovery. Muscle Nerve 58: 566-572, 2018. |
| Databáze: | OpenAIRE |
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