Acute Δ-tetrahydrocannabinol exposure facilitates quinpirole-induced hyperlocomotion
| Autor: | Yolanda de Diego, Miguel Navarro, Belen Ferrer, Fernando Rodríguez de Fonseca, Miguel Angel Gorriti, Emilio Fernández-Espejo, Ignacio del Arco, Francisco Javier Bermúdez-Silva |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Pharmacology
Agonist medicine.medical_specialty Cannabinoid receptor medicine.drug_class Chemistry medicine.medical_treatment Clinical Biochemistry Toxicology Biochemistry Behavioral Neuroscience Quinpirole Endocrinology Dopamine receptor D3 Dopamine receptor Dopamine receptor D2 Internal medicine mental disorders medicine lipids (amino acids peptides and proteins) Cannabinoid Tetrahydrocannabinol Biological Psychiatry medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 81:71-77 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/j.pbb.2005.02.004 |
| Popis: | The endogenous cannabinoid system works as a feedback signal controlling dopamine-induced facilitation of motor behaviors. The present study explored whether a single acute stimulation of CB1 cannabinoid receptors with (-)-Delta9-tetrahydrocannabinol (THC, 5 mg kg(-1) i.p.) results in modifications in the sensitivity to the acute behavioral effects of the dopamine D2/D3 receptor agonist quinpirole (0.025, 0.25 and 1 mg kg(-1), s.c.) 24 h after THC administration. Cannabinoid pretreatment increased the sensitivity to quinpirole-induced hyperlocomotion 24 h after its administration. The data indicated that THC induced a desensitization of cannabinoid receptors, as revealed by a reduction in CB1 receptor-agonist induced GTP-gamma-S incorporation in striatal membranes. These results might be relevant for understanding the effect of cannabinoid exposure in dopamine-related neuropsychiatric disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect