| Autor: |
Jochen Casper, J. Kühl, H. Poliwoda, J. Schubert, Lubomir Arseniev, K. Battmer, O. Bähre, J.G. Kadar, R. J. Berenson, H. Link, H. Diedrich, Roland Jacobs |
| Rok vydání: |
1997 |
| Předmět: |
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| Zdroj: |
Acute Leukemias VI ISBN: 9783642643798 |
| DOI: |
10.1007/978-3-642-60377-8_155 |
| Popis: |
The transplantation of allogeneic peripheral blood progenitor cells (PBPC) could provide durable hematopoietic engraftment. In healthy bone marrow (BM) donors, large amounts of PBPC can be mobilized with hematopoietic growth factors (1–7). However, the high content of immunocompetent T cells in apheresis products may expose recipients of allogeneic PBPC to an elevated risk of acute graft-versus-host disease (aGVHD) [2, 8, 9]. Thus, the use of an appropriate T cell reduction, but not depletion technique might reduce this risk [9, 10]. The hazards of rejection and of a higher relapse rate should be avoided by maintaining a portion of the T cells in the graft [10, 11]. The positive selection of CD34+ cells from peripheral blood preparations simultaneously provides an approximately 1000-fold reduction of T cells [8, 12]. Purified CD34+ cells containing committed and pluripotent stem cells [13–16] may be sufficient for allogeneic transplantation [17]. The aim of the study was the development of a protocol for allogeneic transplantation of PBPC instead of BM cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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