Inhibition of Tumor Necrosis Factor Alpha (TNFα) Expression and FunctionIn Vitroby Modified Antisense Oligonucleotides

Autor:	Anusch Peyman, Nilabh Chaudhary, T. Sudhakar Rao, Joshua O. Ojwang, Shawn D. Mustain, Eugen Uhlmann, Hélène B. Marshall, Robert F. Rando, Ganapathi R. Revankar, David A. Walker
Rok vydání:	1997
Předmět:	Phosphoramidite chemistry.chemical_compound chemistry Oligonucleotide Propynyl Antisense oligonucleotides Genetics Tumor necrosis factor alpha Biochemistry Molecular biology In vitro Function (biology)
Zdroj:	Nucleosides and Nucleotides. 16:1703-1707
ISSN:	0732-8311
Popis:	Antisense oligonucleotides containing C-5 hexynyl/propynyl modified pyrimidines were synthesized using solid phase phosphoramidite chemistry. These modified oligonucleotides were found to have significant inhibitory activity against TNFα production in vitro.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f714de4ab49987bee295b0f83f33d85d https://doi.org/10.1080/07328319708006259 Zobrazit plný text záznamu